SLC26A6 and AQP2

Data Source:
BioGRID (two hybrid)

		SLC26A6	AQP2
Description		solute carrier family 26 member 6	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Brush Border Membrane Vesicle Chloride Channel Complex Sperm Midpiece	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Chloride Channel Activity Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Anion:anion Antiporter Activity Formate Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Formate Efflux Transmembrane Transporter Activity Oxalate Transmembrane Transporter Activity PDZ Domain Binding	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Ion Transport Chloride Transport Sulfate Transport Bicarbonate Transport Formate Transport Mannitol Transport Oxalate Transport Transepithelial Chloride Transport Epithelial Fluid Transport Oxalic Acid Secretion Sperm Capacitation Intestinal Absorption Regulation Of Intracellular PH Intracellular PH Elevation Transepithelial Transport Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Interferon-gamma Sulfate Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Dipeptide Transmembrane Transport	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Multifunctional anion exchangers	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		12 interacting genes: APOL2 AQP2 BET1 CD81 ERG28 LAT PDZK1 PLP1 SNORC TF TMEM128 TMEM201	60 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		65010	359
HPRD ID		10235	00141
Ensembl ID		ENSG00000225697	ENSG00000167580
Uniprot IDs		A0A0C4DFT5 G3XAC1 Q96MZ1 Q9BXS9 Q9Y3Y1	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?