TCAF1 and CNKSR1

Data Source:
BioGRID (two hybrid)

		TCAF1	CNKSR1
Description		TRPM8 channel associated factor 1	connector enhancer of kinase suppressor of Ras 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Protein Binding Ion Channel Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Anion Channel Activity Negative Regulation Of Cell Migration Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Anion Channel Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways			MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS			Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		37 interacting genes: BIRC2 CAMK2A CEP70 CNKSR1 COIL CYSRT1 DISC1 EFEMP2 IKZF3 IKZF4 KRTAP1-3 KRTAP10-8 KRTAP13-2 KRTAP6-3 MAD1L1 MID2 NBPF19 NFYA NOTCH2NLA PRDM14 PRDM6 RBAK SCYL3 SF3B4 SPRY2 TAX1BP1 TCF3 TFIP11 TRAF2 TRIM42 TRIM54 TRIP6 UBC ZNF143 ZNF24 ZNF263 ZNF592	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		9747	10256
HPRD ID		13813	11937
Ensembl ID		ENSG00000198420	ENSG00000142675
Uniprot IDs		B4DST7 Q9Y4C2	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs			1WWV
Enriched GO Terms of Interacting Partners?
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