UBE3C and MTA2

Data Source:
BioGRID (two hybrid)

		UBE3C	MTA2
Description		ubiquitin protein ligase E3C	metastasis associated 1 family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: APP CAND2 CCNB1 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBE2D1 UBE2D2 UBE2D3 UBE2L3	23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1
Entrez ID		9690	9219
HPRD ID		15604	07233
Ensembl ID		ENSG00000009335	ENSG00000149480
Uniprot IDs		Q15386	A0A024R534 O94776
PDB IDs		6K2C
Enriched GO Terms of Interacting Partners?
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