CD53 and CLCN7

Data Source:
BioGRID (two hybrid)

		CD53	CLCN7
Description		CD53 molecule	chloride voltage-gated channel 7
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GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Signal Transduction Neutrophil Degranulation Positive Regulation Of Myoblast Fusion	Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Neutrophil degranulation	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		80 interacting genes: AIG1 APOD ARL13B ASGR2 ATP6V0C BCL2L13 BIK BTN2A2 C1QL4 CD2 CD302 CD37 CD4 CD9 CLCN7 CLDN19 CLDN7 CLEC7A CNIH1 CNIH2 COL4A5 CREB3L1 CTXN3 CXCL16 CYBC1 ECE2 EFNA5 EMP1 ERG28 FAM209A GET1 GGT1 GIMAP5 GJA8 GPR108 GPR152 GPX8 IFITM3 IGFBP5 IL2 IL4 KIR3DL3 LAT LHFPL5 LPAR3 LSMEM1 MAL MS4A3 MUC1 NKG7 PLN PLP2 PMP22 PSCA RPRM SAR1A SERTM1 SLC35A1 SLC7A14 SMAGP SMIM3 SNORC ST6GAL2 STRIT1 STX2 TMEM128 TMEM140 TMEM218 TMEM229B TMEM237 TMEM60 TMEM86B TMEM97 TRAM1L1 TRARG1 TSPO2 UBIAD1 UPK1B VAMP5 VSTM1	17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		963	1186
HPRD ID		01054	04103
Ensembl ID		ENSG00000143119	ENSG00000103249
Uniprot IDs		B4DQB5 P19397	P51798
PDB IDs		6WVG	7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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