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CD53 and IL4
Data Source:
HPRD
(in vivo)
CD53
IL4
Description
CD53 molecule
interleukin 4
Image
GO Annotations
Cellular Component
Immunological Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Specific Granule Membrane
Extracellular Exosome
Tertiary Granule Membrane
Extracellular Region
Extracellular Space
Molecular Function
Protein Binding
Identical Protein Binding
Cytokine Activity
Interleukin-4 Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
Signal Transduction
Neutrophil Degranulation
Positive Regulation Of Myoblast Fusion
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Innate Immune Response In Mucosa
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Acute Inflammatory Response
Negative Regulation Of Chronic Inflammatory Response
Immune Response
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial Cell Migration
Positive Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
B Cell Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
B Cell Costimulation
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
T-helper 2 Cell Cytokine Production
Type 2 Immune Response
Positive Regulation Of T Cell Proliferation
T Cell Activation
Macrophage Activation
Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
T-helper 2 Cell Differentiation
Regulation Of Isotype Switching
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Isotype Switching To IgE Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Negative Regulation Of Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Mononuclear Cell Migration
Dendritic Cell Differentiation
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cold-induced Thermogenesis
Neuroinflammatory Response
Negative Regulation Of Neuroinflammatory Response
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Myoblast Fusion
Positive Regulation Of Cellular Respiration
Negative Regulation Of Complement-dependent Cytotoxicity
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of T-helper 17 Cell Differentiation
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Eosinophil Chemotaxis
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Neutrophil degranulation
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
Drugs
Pascolizumab
Diseases
Asthma
GWAS
Cytomegalovirus antibody response (
21993531
)
Obesity-related traits (
23251661
)
Asthma (
31959851
31619474
29273806
)
Asthma (childhood onset) (
31036433
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
25574825
)
Atopic march (
26542096
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Refractive error (
32231278
)
Interacting Genes
80 interacting genes:
AIG1
APOD
ARL13B
ASGR2
ATP6V0C
BCL2L13
BIK
BTN2A2
C1QL4
CD2
CD302
CD37
CD4
CD9
CLCN7
CLDN19
CLDN7
CLEC7A
CNIH1
CNIH2
COL4A5
CREB3L1
CTXN3
CXCL16
CYBC1
ECE2
EFNA5
EMP1
ERG28
FAM209A
GET1
GGT1
GIMAP5
GJA8
GPR108
GPR152
GPX8
IFITM3
IGFBP5
IL2
IL4
KIR3DL3
LAT
LHFPL5
LPAR3
LSMEM1
MAL
MS4A3
MUC1
NKG7
PLN
PLP2
PMP22
PSCA
RPRM
SAR1A
SERTM1
SLC35A1
SLC7A14
SMAGP
SMIM3
SNORC
ST6GAL2
STRIT1
STX2
TMEM128
TMEM140
TMEM218
TMEM229B
TMEM237
TMEM60
TMEM86B
TMEM97
TRAM1L1
TRARG1
TSPO2
UBIAD1
UPK1B
VAMP5
VSTM1
7 interacting genes:
A2M
CD53
FBXO7
IL13RA2
IL2RG
IL4R
PIK3CD
Entrez ID
963
3565
HPRD ID
01054
00989
Ensembl ID
ENSG00000143119
ENSG00000113520
Uniprot IDs
B4DQB5
P19397
D4HNR6
P05112
Q5FC01
PDB IDs
6WVG
1BBN
1BCN
1CYL
1HIJ
1HIK
1HZI
1IAR
1ILL
1ITE
1ITI
1ITL
1ITM
1RCB
2B8U
2B8X
2B8Y
2B8Z
2B90
2B91
2CYK
2D48
2INT
3BPL
3BPN
3QB7
4YDY
5FHX
6OEL
Enriched GO Terms of Interacting Partners
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