NR1D2 and KRTAP4-2

Data Source:
BioGRID (two hybrid, two hybrid)

		NR1D2	KRTAP4-2
Description		nuclear receptor subfamily 1 group D member 2	keratin associated protein 4-2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Cytosol Keratin Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Lipid Homeostasis Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation	Keratinization
Pathways		Nuclear Receptor transcription pathway	Keratinization
Drugs		SR-9009 SR-9011
Diseases
GWAS		Acne (severe) ( 24927181) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 29273806) Cognitive ability ( 29186694) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278)
Interacting Genes		53 interacting genes: CRY1 CSNK1E CSNK2A2 CUL1 CYSRT1 DELEC1 EFEMP2 GTF2B HDAC1 HOXA1 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS8 MEOX2 MID2 MYLIP MYO15B NBPF19 NCOA5 NCOR1 NOTCH2NLA NR1D1 PCSK5 PRMT6 PROP1 RBPMS RGN RORC SIN3B TAF6 TAF9 TBC1D21 TENT5B TRIM27 TRIM55 TRIM63 TRIP6 UBE2I ZNF587	124 interacting genes: ADAMTSL4 ALDH3B1 AMOTL2 ANKS1A AQP1 ATG9A AVPI1 AXIN1 BAG4 BYSL CATSPER1 CCER1 CELF5 CHIC2 CHRD CRCT1 CREB5 CRY2 CYP21A2 CYSRT1 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT GUCD1 HOXA1 HOXB9 HPCAL1 HSD3B7 ITGB4 KPRP KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP26-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP5-2 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAFB MEOX2 NBPF19 NECTIN3 NLK NOTCH2NLA NR1D2 NR4A3 NTAQ1 NUFIP2 OTX1 OXER1 PDE9A PGLS PHLDA1 PIN1 PLSCR1 PLSCR4 POM121L8P POU4F2 PRKAB2 PRKAG1 PSMA6 RASSF5 RGS20 SDC3 SHFL SLC23A1 SLC25A10 SMCP SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 VASN VGLL3 YY1 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581 ZNF688
Entrez ID		9975	85291
HPRD ID		03809	13944
Ensembl ID		ENSG00000174738	ENSG00000244537
Uniprot IDs		B4DXD3 F1D8P2 Q14995	Q9BYR5
PDB IDs		2V0V 2V7C 3CQV 4N73
Enriched GO Terms of Interacting Partners?
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