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NR2E3 and HDAC3
Data Source:
HPRD
(in vivo)
NR2E3
HDAC3
Description
nuclear receptor subfamily 2 group E member 3
histone deacetylase 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Cyclin Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
NF-kappaB Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Visual Perception
Phototransduction
Negative Regulation Of Cell Population Proliferation
Cell Differentiation
Intracellular Receptor Signaling Pathway
Eye Photoreceptor Cell Development
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Development
Retina Development In Camera-type Eye
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Protein Deacetylation
Circadian Rhythm
Negative Regulation Of Myotube Differentiation
Regulation Of Lipid Metabolic Process
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of TOR Signaling
Circadian Regulation Of Gene Expression
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Spindle Assembly
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Fluid Shear Stress
Positive Regulation Of Cold-induced Thermogenesis
Pathways
NR1D1 (REV-ERBA) represses gene expression
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
Drugs
Vorinostat
Belinostat
Pracinostat
Panobinostat
Mocetinostat
Diseases
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Retinitis pigmentosa (RP)
GWAS
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Metabolite levels (HVA/MHPG ratio) (
23319000
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Interacting Genes
29 interacting genes:
BCL11A
CDK9
CRX
DEDD2
DHX30
ELAVL2
HDAC1
HDAC3
HOXC13
IRF9
MYBBP1A
NCOR1
NR1D1
NR3C1
NRL
POLR3D
PPARG
RARA
RBBP4
RBBP7
RBFOX2
RBL1
RXRA
RXRB
SIN3A
SNAPC1
TBL3
WDR5
ZNF232
102 interacting genes:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRIP1
BRMS1
CBFA2T3
CCN5
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
DAXX
DHX30
EED
ELL
EP300
ESR1
EWSR1
GATA1
GATA2
GATA3
GCM1
GPS2
GTF2I
GTF2IRD1
H2AC1
H2BC1
H3C1
H4C1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1A
HIF1AN
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
XPO1
YY1
ZBTB16
Entrez ID
10002
8841
HPRD ID
05132
08950
Ensembl ID
ENSG00000278570
ENSG00000171720
Uniprot IDs
F1D8Q9
Q9Y5X4
O15379
PDB IDs
4LOG
4A69
Enriched GO Terms of Interacting Partners
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