VPS4B and CHMP5

Data Source:
BioGRID (two hybrid)

		VPS4B	CHMP5
Description		vacuolar protein sorting 4 homolog B	charged multivesicular body protein 5
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Endosome Centrosome Cytosol Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Nucleus Multivesicular Body Cytosol Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity ATPase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Cadherin Binding
	Biological Process	Potassium Ion Transport Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Cholesterol Transport Cytoplasmic Microtubule Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Process Regulation Of Viral Process Microtubule Severing Protein Depolymerization Negative Regulation Of Cell Death Late Endosomal Microautophagy Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation Positive Regulation Of Viral Life Cycle ESCRT III Complex Disassembly	Regulation Of Receptor Recycling Vesicle Budding From Membrane Nucleus Organization Lysosome Organization Mitotic Metaphase Plate Congression Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Midbody Abscission Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction and prostate cancer treatment ( 20932654)
Interacting Genes		8 interacting genes: CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 VPS4A ZFYVE19	16 interacting genes: APPBP2 CHMP1B CHMP4A CHMP4B GTF3A MITD1 NOD2 PDCD10 RPL38 SMARCA4 STAMBP URGCP VPS4B VTA1 ZNF142 ZNF91
Entrez ID		9525	51510
HPRD ID		15653	15408
Ensembl ID		ENSG00000119541	ENSG00000086065
Uniprot IDs		A0A024R2C5 O75351	Q9NZZ3
PDB IDs		1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y	2LXM 3ULY 3UM0 3UM1 3UM2 4TXR
Enriched GO Terms of Interacting Partners?
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