VPS4B and CHMP1A

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		VPS4B	CHMP1A
Description		vacuolar protein sorting 4 homolog B	charged multivesicular body protein 1A
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Endosome Centrosome Cytosol Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Condensed Nuclear Chromosome ESCRT III Complex Early Endosome Multivesicular Body Microtubule Organizing Center Endomembrane System Nuclear Matrix Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity ATPase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Potassium Ion Transport Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Cholesterol Transport Cytoplasmic Microtubule Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Process Regulation Of Viral Process Microtubule Severing Protein Depolymerization Negative Regulation Of Cell Death Late Endosomal Microautophagy Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation Positive Regulation Of Viral Life Cycle ESCRT III Complex Disassembly	Proteolysis Nucleus Organization Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Gene Silencing Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Division Midbody Abscission Regulation Of Mitotic Spindle Assembly ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	HCMV Late Events
Drugs
Diseases
GWAS		Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Estimated glomerular filtration rate ( 31152163) Hemoglobin levels ( 32327693) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Plasma homocysteine levels ( 30339177) Red vs. brown/black hair color ( 30531825)
Interacting Genes		8 interacting genes: CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 VPS4A ZFYVE19	19 interacting genes: C14orf119 CHMP1B DDIT4L GORASP2 IST1 LNPK MITD1 NR1I2 PSMA1 SDCBP STAMBP TXN2 UBE2I USP8 VPS4A VPS4B VTA1 YES1 ZDHHC17
Entrez ID		9525	5119
HPRD ID		15653	01237
Ensembl ID		ENSG00000119541	ENSG00000131165
Uniprot IDs		A0A024R2C5 O75351	Q9HD42
PDB IDs		1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y	2JQ9 2YMB 4A5X
Enriched GO Terms of Interacting Partners?
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