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PICK1 and ATXN3
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PICK1
ATXN3
Description
protein interacting with PRKCA 1
ataxin 3
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Synaptic Vesicle
Postsynaptic Density
Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Presynaptic Membrane
Neuron Projection
Synapse
Perinuclear Region Of Cytoplasm
Postsynaptic Early Endosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Nuclear Matrix
Mitochondrial Membrane
Nuclear Inclusion Body
Synapse
Molecular Function
G Protein-coupled Receptor Binding
Protein Kinase C Binding
Signaling Receptor Binding
Protein Binding
Phospholipid Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Actin Filament Binding
Arp2/3 Complex Binding
Membrane Curvature Sensor Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
ATPase Binding
Lys63-specific Deubiquitinase Activity
Lys48-specific Deubiquitinase Activity
Biological Process
Positive Regulation Of Receptor Internalization
Protein Phosphorylation
Intracellular Protein Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Monoamine Transport
Glial Cell Development
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cellular Response To Decreased Oxygen Levels
Cellular Response To Glucose Starvation
DNA Methylation Involved In Embryo Development
DNA Methylation Involved In Gamete Generation
Receptor Clustering
Neuronal Ion Channel Clustering
Regulation Of Insulin Secretion
Long-term Synaptic Depression
Dendritic Spine Organization
Dendritic Spine Maintenance
Microtubule Cytoskeleton Organization
Nucleotide-excision Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Chemical Synaptic Transmission
Nervous System Development
Regulation Of Cell-substrate Adhesion
Protein Deubiquitination
Protein Phosphopantetheinylation
Actin Cytoskeleton Organization
Cellular Response To Heat
Monoubiquitinated Protein Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Misfolded Protein
Positive Regulation Of ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways
Cell surface interactions at the vascular wall
Trafficking of GluR2-containing AMPA receptors
Josephin domain DUBs
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Body fat percentage (
26833246
)
Brain morphology (MOSTest) (
32665545
)
Mean platelet volume (
32888494
)
Amyotrophic lateral sclerosis (
29566793
)
Coronary artery calcification (
23870195
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Height (
18391950
18391951
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Orofacial clefts (
22419666
)
Refractive error (
32231278
)
Interacting Genes
365 interacting genes:
ABT1
AEBP2
AFDN
AKT1
AKT2
ALKBH8
AP1M1
AP1S1
APTX
AQP1
ARF1
ARF3
ARHGEF3
ARHGEF5
ARL6IP1
ARMCX1
ASIC1
ASIC2
ATP5IF1
ATXN1L
ATXN3
ATXN7
ATXN7L3
AVPI1
BAHD1
BCL2L14
BEX1
BLK
BLOC1S2
BOLA3
BRD1
BTG2
BUD31
BYSL
C1orf35
C2CD5
C4orf46
C8orf33
CARD9
CBX8
CCDC102B
CCDC103
CCDC187
CCNH
CDC42EP2
CDC73
CDCA7L
CDK2AP1
CDKL3
CDKN2B
CDKN2D
CEP19
CEP290
CEP57L1
CEP89
CEP95
CGGBP1
CHMP1B
CIC
COIL
CPNE2
CPNE7
CRY2
CSNK2A2
CTNNB1
CTSG
CUTC
CWF19L2
CYP21A2
DCTD
DCUN1D5
DDX55
DDX6
DMC1
DMD
DNAJB13
DNTTIP1
DNTTIP2
DPF2
DRAP1
DTNB
DUSP29
EAF1
EEF2KMT
EFHC2
EFNB1
EFNB2
EHD2
EHHADH
EIF1AD
EIF3D
EIF4A3
EIF4EBP1
EIF4H
EIF5A
ENKD1
EPHB2
EPM2AIP1
ERBB2
ERBIN
ESCO2
EXOSC5
F11R
FAM161A
FAM161B
FAM207A
FAM214B
FAM219B
FAM90A1
FAM9A
FBXL3
FBXL8
FGF16
FKBP6
FLYWCH1
FXN
GADD45GIP1
GAS2L2
GFI1
GFI1B
GLYCTK
GPATCH11
GPATCH2
GPC4
GPKOW
GRB10
GRB7
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRIP1
GRM3
GRM7
GRXCR1
GTF2E2
GTPBP2
HDAC4
HEXIM2
HMBOX1
HMBS
HMG20A
HOPX
HOXA5
HSD17B14
HSF2
HSF2BP
ID2
IHO1
IL16
ILF2
INO80B
INO80E
INPP5J
IP6K1
ISCU
JAM3
JRK
KAT5
KCTD1
KCTD6
KCTD9
KIAA1328
L3MBTL2
LCLAT1
LCN2
LGALS14
LMO1
LMO3
LONRF1
LRP2BP
LRRC73
LZTFL1
LZTS1
MAGEA4
MAGEB4
MAP2K6
MAPK9
MAPRE3
MAZ
MBD3
MCM10
MEOX2
MGME1
MID2
MNS1
MOB3C
MORF4L1
MORF4L2
MORN3
MOS
MRI1
MRNIP
MSRB3
MSS51
MTA1
MTG1
NATD1
NCOA5
NDEL1
NECAB2
NECTIN2
NECTIN4
NEK6
NME7
NMNAT1
NOC4L
OARD1
OPTN
OSBP2
OSGIN1
OSTF1
PAFAH1B3
PAX6
PBX4
PCBD1
PDCD5
PDS5A
PEBP1
PHF19
PIBF1
PKN1
PKNOX2
PLEKHA7
PNKP
PNO1
POLL
POLR3C
PPARA
PPL
PRKCA
PRKCG
PRKN
PRLHR
PRPF18
PRPF31
PRPF40A
PSMA1
PSME3
PTRH1
QARS1
RAD51D
RASAL3
REEP6
REL
RFC3
RIMS3
RIN1
RNF8
RNPS1
ROBO3
ROPN1
RPIA
RPP25
RRP8
RXRB
RXRG
SACS
SCAND1
SCNM1
SEMA3B
SEPTIN1
SERBP1
SERTAD1
SERTAD3
SH2D4A
SH3GLB2
SHFL
SLC6A3
SLIRP
SMARCB1
SMARCD1
SNRNP25
SNRPA1
SNRPB2
SNW1
SPANXN2
SPATC1L
SPEG
SSNA1
STK19
STK4
SYT17
TBC1D22B
TBC1D26
TBC1D7
TCEA2
TCEANC
TCEANC2
TDO2
TEX101
TFIP11
THAP6
THAP7
TLE5
TLNRD1
TPM4
TRAF4
TRAF5
TRIM44
TRIM54
TRIML2
TRMT2A
TSGA10IP
TSN
TSTD2
TTC23
TTC23L
TXNDC9
TXNL4B
TYW3
UBE2E3
UBE2K
UBQLN4
USHBP1
USP2
USP7
UTP3
VAX1
VEZF1
VPS25
WT1
XPA
YES1
YPEL2
YTHDC1
ZBED1
ZBTB2
ZBTB24
ZBTB49
ZFHX3
ZFP2
ZFP91
ZMAT2
ZMYND12
ZNF165
ZNF17
ZNF205
ZNF250
ZNF264
ZNF276
ZNF286A
ZNF329
ZNF330
ZNF35
ZNF408
ZNF410
ZNF414
ZNF417
ZNF438
ZNF497
ZNF524
ZNF575
ZNF576
ZNF593
ZNF624
ZNF691
ZNF71
ZNF764
ZNF774
ZSCAN21
ZSCAN23
ZZZ3
53 interacting genes:
ANXA7
APP
ARHGAP19
ARHGDIA
ASIC1
CAPN1
CAPN2
CASP1
CDKN1A
CHEK1
CSNK2B
DNM2
EWSR1
GABARAP
GSK3B
HDAC6
KAT2B
MAP1LC3A
MAP1LC3C
MAP3K1
MKNK1
NCOR1
NEDD8
PHAF1
PICK1
PJA1
PRKN
PSMD7
RAD23A
RAD23B
RFFL
RPS6KA1
SMURF1
SQSTM1
STUB1
SUMO1
TEX11
TK1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TUBA1A
TUBB
UBB
UBC
UBE2L3
UBE2S
UBE4B
UBQLN1
USP21
VCP
Entrez ID
9463
4287
HPRD ID
16176
06131
Ensembl ID
ENSG00000100151
ENSG00000066427
Uniprot IDs
A0A024R1J5
Q9NRD5
A0A0A0MS38
C9JQV6
P54252
PDB IDs
2GZV
6AR4
6BJN
6BJO
1YZB
2AGA
2DOS
2JRI
2KLZ
4WTH
4YS9
Enriched GO Terms of Interacting Partners
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