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PICK1 and EPHB2
Data Source:
HPRD
(two hybrid, in vitro)
PICK1
EPHB2
Description
protein interacting with PRKCA 1
EPH receptor B2
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Synaptic Vesicle
Postsynaptic Density
Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Presynaptic Membrane
Neuron Projection
Synapse
Perinuclear Region Of Cytoplasm
Postsynaptic Early Endosome
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Axon
Dendrite
Neuron Projection
Neuronal Cell Body
Receptor Complex
Postsynapse
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Molecular Function
G Protein-coupled Receptor Binding
Protein Kinase C Binding
Signaling Receptor Binding
Protein Binding
Phospholipid Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Actin Filament Binding
Arp2/3 Complex Binding
Membrane Curvature Sensor Activity
Amyloid-beta Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Axon Guidance Receptor Activity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Positive Regulation Of Receptor Internalization
Protein Phosphorylation
Intracellular Protein Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Monoamine Transport
Glial Cell Development
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cellular Response To Decreased Oxygen Levels
Cellular Response To Glucose Starvation
DNA Methylation Involved In Embryo Development
DNA Methylation Involved In Gamete Generation
Receptor Clustering
Neuronal Ion Channel Clustering
Regulation Of Insulin Secretion
Long-term Synaptic Depression
Dendritic Spine Organization
Dendritic Spine Maintenance
Angiogenesis
Urogenital System Development
Negative Regulation Of Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Axonal Fasciculation
Learning Or Memory
Learning
Positive Regulation Of Gene Expression
Phosphorylation
Peptidyl-tyrosine Phosphorylation
Optic Nerve Morphogenesis
Central Nervous System Projection Neuron Axonogenesis
Corpus Callosum Development
Regulation Of Blood Coagulation
Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Synaptic Plasticity
Positive Regulation Of Kinase Activity
Inner Ear Morphogenesis
Negative Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Camera-type Eye Morphogenesis
Negative Regulation Of Axonogenesis
Regulation Of Body Fluid Levels
Inactivation Of MAPKK Activity
Positive Regulation Of Synapse Assembly
Roof Of Mouth Development
Dendritic Spine Development
Dendritic Spine Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Commissural Neuron Axon Guidance
Postsynaptic Membrane Assembly
Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Neuron Projection Retraction
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of NMDA Glutamate Receptor Activity
Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways
Cell surface interactions at the vascular wall
Trafficking of GluR2-containing AMPA receptors
EPH-Ephrin signaling
EPH-Ephrin signaling
L1CAM interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Fostamatinib
Diseases
GWAS
Body fat percentage (
26833246
)
Brain morphology (MOSTest) (
32665545
)
Mean platelet volume (
32888494
)
Blood protein levels (
30072576
29875488
28240269
)
Refractive error (
32231278
)
Triiodothyronine levels (
30843173
)
Triiodothyronine levels and thyroxine levels (
30843173
)
Interacting Genes
365 interacting genes:
ABT1
AEBP2
AFDN
AKT1
AKT2
ALKBH8
AP1M1
AP1S1
APTX
AQP1
ARF1
ARF3
ARHGEF3
ARHGEF5
ARL6IP1
ARMCX1
ASIC1
ASIC2
ATP5IF1
ATXN1L
ATXN3
ATXN7
ATXN7L3
AVPI1
BAHD1
BCL2L14
BEX1
BLK
BLOC1S2
BOLA3
BRD1
BTG2
BUD31
BYSL
C1orf35
C2CD5
C4orf46
C8orf33
CARD9
CBX8
CCDC102B
CCDC103
CCDC187
CCNH
CDC42EP2
CDC73
CDCA7L
CDK2AP1
CDKL3
CDKN2B
CDKN2D
CEP19
CEP290
CEP57L1
CEP89
CEP95
CGGBP1
CHMP1B
CIC
COIL
CPNE2
CPNE7
CRY2
CSNK2A2
CTNNB1
CTSG
CUTC
CWF19L2
CYP21A2
DCTD
DCUN1D5
DDX55
DDX6
DMC1
DMD
DNAJB13
DNTTIP1
DNTTIP2
DPF2
DRAP1
DTNB
DUSP29
EAF1
EEF2KMT
EFHC2
EFNB1
EFNB2
EHD2
EHHADH
EIF1AD
EIF3D
EIF4A3
EIF4EBP1
EIF4H
EIF5A
ENKD1
EPHB2
EPM2AIP1
ERBB2
ERBIN
ESCO2
EXOSC5
F11R
FAM161A
FAM161B
FAM207A
FAM214B
FAM219B
FAM90A1
FAM9A
FBXL3
FBXL8
FGF16
FKBP6
FLYWCH1
FXN
GADD45GIP1
GAS2L2
GFI1
GFI1B
GLYCTK
GPATCH11
GPATCH2
GPC4
GPKOW
GRB10
GRB7
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRIP1
GRM3
GRM7
GRXCR1
GTF2E2
GTPBP2
HDAC4
HEXIM2
HMBOX1
HMBS
HMG20A
HOPX
HOXA5
HSD17B14
HSF2
HSF2BP
ID2
IHO1
IL16
ILF2
INO80B
INO80E
INPP5J
IP6K1
ISCU
JAM3
JRK
KAT5
KCTD1
KCTD6
KCTD9
KIAA1328
L3MBTL2
LCLAT1
LCN2
LGALS14
LMO1
LMO3
LONRF1
LRP2BP
LRRC73
LZTFL1
LZTS1
MAGEA4
MAGEB4
MAP2K6
MAPK9
MAPRE3
MAZ
MBD3
MCM10
MEOX2
MGME1
MID2
MNS1
MOB3C
MORF4L1
MORF4L2
MORN3
MOS
MRI1
MRNIP
MSRB3
MSS51
MTA1
MTG1
NATD1
NCOA5
NDEL1
NECAB2
NECTIN2
NECTIN4
NEK6
NME7
NMNAT1
NOC4L
OARD1
OPTN
OSBP2
OSGIN1
OSTF1
PAFAH1B3
PAX6
PBX4
PCBD1
PDCD5
PDS5A
PEBP1
PHF19
PIBF1
PKN1
PKNOX2
PLEKHA7
PNKP
PNO1
POLL
POLR3C
PPARA
PPL
PRKCA
PRKCG
PRKN
PRLHR
PRPF18
PRPF31
PRPF40A
PSMA1
PSME3
PTRH1
QARS1
RAD51D
RASAL3
REEP6
REL
RFC3
RIMS3
RIN1
RNF8
RNPS1
ROBO3
ROPN1
RPIA
RPP25
RRP8
RXRB
RXRG
SACS
SCAND1
SCNM1
SEMA3B
SEPTIN1
SERBP1
SERTAD1
SERTAD3
SH2D4A
SH3GLB2
SHFL
SLC6A3
SLIRP
SMARCB1
SMARCD1
SNRNP25
SNRPA1
SNRPB2
SNW1
SPANXN2
SPATC1L
SPEG
SSNA1
STK19
STK4
SYT17
TBC1D22B
TBC1D26
TBC1D7
TCEA2
TCEANC
TCEANC2
TDO2
TEX101
TFIP11
THAP6
THAP7
TLE5
TLNRD1
TPM4
TRAF4
TRAF5
TRIM44
TRIM54
TRIML2
TRMT2A
TSGA10IP
TSN
TSTD2
TTC23
TTC23L
TXNDC9
TXNL4B
TYW3
UBE2E3
UBE2K
UBQLN4
USHBP1
USP2
USP7
UTP3
VAX1
VEZF1
VPS25
WT1
XPA
YES1
YPEL2
YTHDC1
ZBED1
ZBTB2
ZBTB24
ZBTB49
ZFHX3
ZFP2
ZFP91
ZMAT2
ZMYND12
ZNF165
ZNF17
ZNF205
ZNF250
ZNF264
ZNF276
ZNF286A
ZNF329
ZNF330
ZNF35
ZNF408
ZNF410
ZNF414
ZNF417
ZNF438
ZNF497
ZNF524
ZNF575
ZNF576
ZNF593
ZNF624
ZNF691
ZNF71
ZNF764
ZNF774
ZSCAN21
ZSCAN23
ZZZ3
39 interacting genes:
ABL1
ABL2
ACP1
AFDN
AQP1
ARHGEF6
CRK
EFNA5
EFNB1
EFNB2
ERBB2
ERF
FBXO7
FOS
GRB2
GRIN1
GRIN2B
ITSN1
KALRN
KSR1
MMP2
MMP9
MTMR14
NCK1
PICK1
PLCG1
PTK2
RASA1
RRAS
RYK
SDC2
SDCBP
SH2D3C
SRC
SYNJ1
TRIM54
VAV2
VEGFA
YES1
Entrez ID
9463
2048
HPRD ID
16176
02997
Ensembl ID
ENSG00000100151
ENSG00000133216
Uniprot IDs
A0A024R1J5
Q9NRD5
B4DSE0
P29323
Q4LE53
Q6NVW1
PDB IDs
2GZV
6AR4
6BJN
6BJO
1B4F
1F0M
2QBX
3ZFM
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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