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PICK1 and PPARA
Data Source:
BioGRID
(two hybrid)
PICK1
PPARA
Description
protein interacting with PRKCA 1
peroxisome proliferator activated receptor alpha
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Synaptic Vesicle
Postsynaptic Density
Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Presynaptic Membrane
Neuron Projection
Synapse
Perinuclear Region Of Cytoplasm
Postsynaptic Early Endosome
Chromatin
Nucleus
Nucleoplasm
Molecular Function
G Protein-coupled Receptor Binding
Protein Kinase C Binding
Signaling Receptor Binding
Protein Binding
Phospholipid Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Actin Filament Binding
Arp2/3 Complex Binding
Membrane Curvature Sensor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Drug Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Conjugating Enzyme Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NFAT Protein Binding
MDM2/MDM4 Family Protein Binding
Biological Process
Positive Regulation Of Receptor Internalization
Protein Phosphorylation
Intracellular Protein Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Monoamine Transport
Glial Cell Development
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cellular Response To Decreased Oxygen Levels
Cellular Response To Glucose Starvation
DNA Methylation Involved In Embryo Development
DNA Methylation Involved In Gamete Generation
Receptor Clustering
Neuronal Ion Channel Clustering
Regulation Of Insulin Secretion
Long-term Synaptic Depression
Dendritic Spine Organization
Dendritic Spine Maintenance
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Transcription Initiation From RNA Polymerase II Promoter
Fatty Acid Metabolic Process
Heart Development
Epidermis Development
Cellular Response To Starvation
Hormone-mediated Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Localization
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Regulation Of Lipid Metabolic Process
Regulation Of Fatty Acid Metabolic Process
Cell Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Protein Binding
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Lipid
Behavioral Response To Nicotine
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Viral Genome Replication
Response To Ethanol
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Inflammatory Response
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Enamel Mineralization
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neuron Death
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Hepatocyte Apoptotic Process
Regulation Of Fatty Acid Transport
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Pathways
Cell surface interactions at the vascular wall
Trafficking of GluR2-containing AMPA receptors
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Drugs
alpha-Linolenic acid
Icosapent
Troglitazone
Valproic acid
Indomethacin
Rosiglitazone
Fenoprofen
Clofibrate
Fenofibrate
Ibuprofen
Amiodarone
Gemfibrozil
Bezafibrate
Prasterone
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
Flufenamic acid
Resveratrol
Phthalic Acid
Lauric acid
Stearic acid
Doconexent
Palmitic Acid
Oleic Acid
Caprylic acid
Arachidonic Acid
Reglitazar
Elafibranor
Cardarine
Muraglitazar
Ertiprotafib
Ragaglitazar
Tesaglitazar
GW-590735
Indeglitazar
Myristic acid
Aleglitazar
Clinofibrate
Ciprofibrate
Dexibuprofen
Soybean oil
Omega-3 fatty acids
Myrrh
Isoflavone
Leukotriene B4
Fenofibric acid
Fish oil
Diseases
GWAS
Body fat percentage (
26833246
)
Brain morphology (MOSTest) (
32665545
)
Mean platelet volume (
32888494
)
Cholesterol, total (
24097068
)
CTACK levels (
27989323
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Impulsivity (motor) (
30718321
)
LDL cholesterol (
24097068
)
Refractive error (
32231278
)
Resting-state electroencephalogram vigilance (
29703947
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
31049640
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Interacting Genes
365 interacting genes:
ABT1
AEBP2
AFDN
AKT1
AKT2
ALKBH8
AP1M1
AP1S1
APTX
AQP1
ARF1
ARF3
ARHGEF3
ARHGEF5
ARL6IP1
ARMCX1
ASIC1
ASIC2
ATP5IF1
ATXN1L
ATXN3
ATXN7
ATXN7L3
AVPI1
BAHD1
BCL2L14
BEX1
BLK
BLOC1S2
BOLA3
BRD1
BTG2
BUD31
BYSL
C1orf35
C2CD5
C4orf46
C8orf33
CARD9
CBX8
CCDC102B
CCDC103
CCDC187
CCNH
CDC42EP2
CDC73
CDCA7L
CDK2AP1
CDKL3
CDKN2B
CDKN2D
CEP19
CEP290
CEP57L1
CEP89
CEP95
CGGBP1
CHMP1B
CIC
COIL
CPNE2
CPNE7
CRY2
CSNK2A2
CTNNB1
CTSG
CUTC
CWF19L2
CYP21A2
DCTD
DCUN1D5
DDX55
DDX6
DMC1
DMD
DNAJB13
DNTTIP1
DNTTIP2
DPF2
DRAP1
DTNB
DUSP29
EAF1
EEF2KMT
EFHC2
EFNB1
EFNB2
EHD2
EHHADH
EIF1AD
EIF3D
EIF4A3
EIF4EBP1
EIF4H
EIF5A
ENKD1
EPHB2
EPM2AIP1
ERBB2
ERBIN
ESCO2
EXOSC5
F11R
FAM161A
FAM161B
FAM207A
FAM214B
FAM219B
FAM90A1
FAM9A
FBXL3
FBXL8
FGF16
FKBP6
FLYWCH1
FXN
GADD45GIP1
GAS2L2
GFI1
GFI1B
GLYCTK
GPATCH11
GPATCH2
GPC4
GPKOW
GRB10
GRB7
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRIP1
GRM3
GRM7
GRXCR1
GTF2E2
GTPBP2
HDAC4
HEXIM2
HMBOX1
HMBS
HMG20A
HOPX
HOXA5
HSD17B14
HSF2
HSF2BP
ID2
IHO1
IL16
ILF2
INO80B
INO80E
INPP5J
IP6K1
ISCU
JAM3
JRK
KAT5
KCTD1
KCTD6
KCTD9
KIAA1328
L3MBTL2
LCLAT1
LCN2
LGALS14
LMO1
LMO3
LONRF1
LRP2BP
LRRC73
LZTFL1
LZTS1
MAGEA4
MAGEB4
MAP2K6
MAPK9
MAPRE3
MAZ
MBD3
MCM10
MEOX2
MGME1
MID2
MNS1
MOB3C
MORF4L1
MORF4L2
MORN3
MOS
MRI1
MRNIP
MSRB3
MSS51
MTA1
MTG1
NATD1
NCOA5
NDEL1
NECAB2
NECTIN2
NECTIN4
NEK6
NME7
NMNAT1
NOC4L
OARD1
OPTN
OSBP2
OSGIN1
OSTF1
PAFAH1B3
PAX6
PBX4
PCBD1
PDCD5
PDS5A
PEBP1
PHF19
PIBF1
PKN1
PKNOX2
PLEKHA7
PNKP
PNO1
POLL
POLR3C
PPARA
PPL
PRKCA
PRKCG
PRKN
PRLHR
PRPF18
PRPF31
PRPF40A
PSMA1
PSME3
PTRH1
QARS1
RAD51D
RASAL3
REEP6
REL
RFC3
RIMS3
RIN1
RNF8
RNPS1
ROBO3
ROPN1
RPIA
RPP25
RRP8
RXRB
RXRG
SACS
SCAND1
SCNM1
SEMA3B
SEPTIN1
SERBP1
SERTAD1
SERTAD3
SH2D4A
SH3GLB2
SHFL
SLC6A3
SLIRP
SMARCB1
SMARCD1
SNRNP25
SNRPA1
SNRPB2
SNW1
SPANXN2
SPATC1L
SPEG
SSNA1
STK19
STK4
SYT17
TBC1D22B
TBC1D26
TBC1D7
TCEA2
TCEANC
TCEANC2
TDO2
TEX101
TFIP11
THAP6
THAP7
TLE5
TLNRD1
TPM4
TRAF4
TRAF5
TRIM44
TRIM54
TRIML2
TRMT2A
TSGA10IP
TSN
TSTD2
TTC23
TTC23L
TXNDC9
TXNL4B
TYW3
UBE2E3
UBE2K
UBQLN4
USHBP1
USP2
USP7
UTP3
VAX1
VEZF1
VPS25
WT1
XPA
YES1
YPEL2
YTHDC1
ZBED1
ZBTB2
ZBTB24
ZBTB49
ZFHX3
ZFP2
ZFP91
ZMAT2
ZMYND12
ZNF165
ZNF17
ZNF205
ZNF250
ZNF264
ZNF276
ZNF286A
ZNF329
ZNF330
ZNF35
ZNF408
ZNF410
ZNF414
ZNF417
ZNF438
ZNF497
ZNF524
ZNF575
ZNF576
ZNF593
ZNF624
ZNF691
ZNF71
ZNF764
ZNF774
ZSCAN21
ZSCAN23
ZZZ3
70 interacting genes:
AIP
AKAP13
ANKRD11
AQP1
BCL2
CCDC179
CDC34
CDK3
CEP350
CHD9
CHIC2
COL8A1
CTNNA3
DAP3
DUT
EP300
EXOSC4
FABP1
FAM90A1
FAM9B
FBLN1
FOXA3
GADD45A
GADD45B
GADD45G
GPANK1
HELZ2
HOXC8
HSP90AA1
KCTD7
KRTAP10-1
LAMTOR5
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H2
NR1H3
NRBF2
NRIP1
PAQR3
PICK1
PIK3R3
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SDCBP
SIRT1
STAC3
TNP1
TRIM55
TRIM63
UBE2I
VWA5A
VWC2L
ZNF587
ZSCAN23
Entrez ID
9463
5465
HPRD ID
16176
01369
Ensembl ID
ENSG00000100151
ENSG00000186951
Uniprot IDs
A0A024R1J5
Q9NRD5
F1D8S4
Q07869
PDB IDs
2GZV
6AR4
6BJN
6BJO
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
4CI4
5AZT
5HYK
6KXX
6KXY
6L96
Enriched GO Terms of Interacting Partners
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