GSTO1 and SERPINB5

Data Source:
BioGRID (two hybrid)

		GSTO1	SERPINB5
Description		glutathione S-transferase omega 1	serpin family B member 5
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Extracellular Space Cytoplasm
	Molecular Function	Glutathione Transferase Activity Protein Binding Oxidoreductase Activity Glutathione Dehydrogenase (ascorbate) Activity Methylarsonate Reductase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Glutathione Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion L-ascorbic Acid Metabolic Process Methylation Interleukin-12-mediated Signaling Pathway Xenobiotic Catabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Arsenic-containing Substance Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis
Pathways		Methylation Glutathione conjugation Vitamin C (ascorbate) metabolism Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Glutathione	S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)
Interacting Genes		8 interacting genes: APP CEP126 EEF1G HSPB1 KAT5 RBM48 SERPINB5 SETDB1	26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3
Entrez ID		9446	5268
HPRD ID		10401	01111
Ensembl ID		ENSG00000148834	ENSG00000206075
Uniprot IDs		P78417 V9HWG9	A0A024R2B6 P36952
PDB IDs		1EEM 3LFL 3VLN 4IS0 4YQM 4YQU 4YQV 5UEH 5V3Q 5YVN 5YVO 6MHB 6MHC 6MHD 6PNM 6PNN 6PNO	1WZ9 1XQG 1XQJ 1XU8
Enriched GO Terms of Interacting Partners?
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