NTN1 and NEO1

Data Source:
HPRD (in vitro, in vivo)

		NTN1	NEO1
Description		netrin 1	neogenin 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Cytoplasm	Nucleoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Plasma Membrane Protein Complex
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Activity Co-receptor Binding
	Biological Process	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility	Cell Adhesion Axon Guidance Positive Regulation Of BMP Signaling Pathway Iron Ion Homeostasis
Pathways		Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO	Netrin-1 signaling Myogenesis
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 33137956 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)	Adventurousness ( 30643258) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Dentures ( 31235808) Face memory ( 31596458) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Red cell distribution width ( 32888494) Resting heart rate ( 27798624) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C	6 interacting genes: MTDH NTN1 NTN3 PITPNA PTK2 TTN
Entrez ID		9423	4756
HPRD ID		03368	03549
Ensembl ID		ENSG00000065320	ENSG00000067141
Uniprot IDs		O95631	Q59FP8 Q92859
PDB IDs		4URT 6FKQ	1X5F 1X5G 1X5H 1X5I 1X5J 1X5K 3P4L
Enriched GO Terms of Interacting Partners?
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