NEO1 and NTN1

Data Source:
HPRD (in vitro, in vivo)

		NEO1	NTN1
Description		neogenin 1	netrin 1
Image
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Plasma Membrane Protein Complex	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	Protein Binding Signaling Receptor Activity Co-receptor Binding	Protein Binding
	Biological Process	Cell Adhesion Axon Guidance Positive Regulation Of BMP Signaling Pathway Iron Ion Homeostasis	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility
Pathways		Netrin-1 signaling Myogenesis	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Dentures ( 31235808) Face memory ( 31596458) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Red cell distribution width ( 32888494) Resting heart rate ( 27798624) Urate levels ( 31578528)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 33137956 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		6 interacting genes: MTDH NTN1 NTN3 PITPNA PTK2 TTN	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		4756	9423
HPRD ID		03549	03368
Ensembl ID		ENSG00000067141	ENSG00000065320
Uniprot IDs		Q59FP8 Q92859	O95631
PDB IDs		1X5F 1X5G 1X5H 1X5I 1X5J 1X5K 3P4L	4URT 6FKQ
Enriched GO Terms of Interacting Partners?
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