NTN1 and UNC5C

Data Source:
HPRD (in vitro)

		NTN1	UNC5C
Description		netrin 1	unc-5 netrin receptor C
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Cytoplasm	Plasma Membrane Cell Surface Integral Component Of Membrane Lamellipodium Filopodium Dendrite Growth Cone Neuronal Cell Body Synapse
	Molecular Function	Protein Binding	Netrin Receptor Activity Netrin Receptor Activity Involved In Chemorepulsion Protein Binding Tubulin Binding Protein Kinase Binding
	Biological Process	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility	Apoptotic Process Axon Guidance Brain Development Regulation Of Cell Migration Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process Chemorepulsion Of Axon Dorsal Root Ganglion Development
Pathways		Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO	Netrin mediated repulsion signals
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 33137956 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)	Adult body size ( 32376654) Alcohol dependence symptom count ( 29460428) Blood protein levels ( 30072576 29875488) Cerebrospinal P-tau181p levels ( 20932310) Coronary artery disease ( 29212778) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 29317602) Maximum stenosis ( 32469969) Obesity-related traits ( 23251661) Obsessive-compulsive symptoms ( 26859814) Optic nerve measurement (cup-to-disc ratio) ( 20395239) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Residual cognition ( 28441426) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Type 2 diabetes ( 31049640)
Interacting Genes		5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C	2 interacting genes: DAPK1 NTN1
Entrez ID		9423	8633
HPRD ID		03368	04678
Ensembl ID		ENSG00000065320	ENSG00000182168
Uniprot IDs		O95631	A8K385 O95185
PDB IDs		4URT 6FKQ
Enriched GO Terms of Interacting Partners?
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