NTN1 and UNC5A

Data Source:
BioGRID (pull down)

		NTN1	UNC5A
Description		netrin 1	unc-5 netrin receptor A
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Cytoplasm	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuron Projection Membrane Neuronal Cell Body Membrane Membrane Raft
	Molecular Function	Protein Binding	Netrin Receptor Activity
	Biological Process	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility	Apoptotic Process Axon Guidance Neuron Projection Development Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway
Pathways		Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO	Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 33137956 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C	3 interacting genes: DAPK1 MAGED1 NTN1
Entrez ID		9423	90249
HPRD ID		03368	12131
Ensembl ID		ENSG00000065320	ENSG00000113763
Uniprot IDs		O95631	H0Y8R2 Q6ZN44
PDB IDs		4URT 6FKQ	4V2A
Enriched GO Terms of Interacting Partners?
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