MVB12A and SH3KBP1

Data Source:
HPRD (in vivo)

		MVB12A	SH3KBP1
Description		multivesicular body subunit 12A	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Golgi Apparatus Centrosome Cytosol Endosome Membrane Late Endosome Membrane Vesicle Host Cell Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding Lipid Binding SH3 Domain Binding Ubiquitin Binding	Protein Binding SH3 Domain Binding
	Biological Process	Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Virus Maturation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Receptor Catabolic Process Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Intracellular Transport Of Virus	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS			Platelet count ( 32888494)
Interacting Genes		6 interacting genes: APP CD2AP HSF2BP OXTR PPP1R27 SH3KBP1	58 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		93343	30011
HPRD ID		14298	02301
Ensembl ID		ENSG00000141971	ENSG00000147010
Uniprot IDs		A0A024R7L6 Q96EY5	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		6VME	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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