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SH3KBP1 and STAP1
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)
SH3KBP1
STAP1
Description
SH3 domain containing kinase binding protein 1
signal transducing adaptor family member 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Endocytic Vesicle
Cytoplasmic Vesicle Membrane
Neuron Projection
Synapse
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
SH3 Domain Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Macrophage Colony-stimulating Factor Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Signaling Adaptor Activity
Biological Process
Endocytosis
Apoptotic Process
Cytoskeleton Organization
Actin Filament Organization
Cell-cell Signaling
Axon Guidance
Regulation Of Cell Shape
Cell Migration
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of B Cell Activation
Membrane Organization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Macrophage Chemotaxis
Negative Regulation Of Phosphorylation
Positive Regulation Of B Cell Receptor Signaling Pathway
Positive Regulation Of Phagocytosis, Engulfment
Cellular Response To Lipopolysaccharide
Negative Regulation Of Ruffle Assembly
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Positive Regulation Of Microglial Cell Activation
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Negative Regulation Of Microglial Cell Migration
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Reelin signalling pathway
InlB-mediated entry of Listeria monocytogenes into host cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS
Platelet count (
32888494
)
Regular attendance at a pub or social club (
29970889
)
Interacting Genes
58 interacting genes:
ABI2
ANKS1A
ARAP3
ARHGAP27
ASAP1
ASAP2
BCAR1
BHLHB9
BLNK
BMPR1B
CAPZA1
CBL
CBLB
CCDC57
CCDC88B
CD2
CYSRT1
DENND2A
GGN
GRB2
HCK
HIVEP1
INPP5D
ITSN2
KPRP
KRTAP6-3
LZTS2
MVB12A
NEDD4
NELFA
PAK2
PDCD6
PDCD6IP
PIK3CA
PIK3R1
PNMA5
POLR2K
PSMA3
SEPTIN2
SEPTIN6
SH3BP2
SH3GL2
SH3GL3
SH3GLB1
SH3GLB2
SHKBP1
SOS1
SPRY2
STAP1
SYNJ1
TAF6
TJP2
TP53BP2
UBB
UBC
UBE2I
ZBTB7B
ZNF219
14 interacting genes:
AR
EGFR
ERBB2
ERBB3
ERBB4
GAB1
GRIPAP1
KIT
MET
PTK2B
RETREG3
SH3KBP1
TEC
URI1
Entrez ID
30011
26228
HPRD ID
02301
16053
Ensembl ID
ENSG00000147010
ENSG00000035720
Uniprot IDs
B7Z6E8
Q5JPT6
Q96B97
A0A024RD91
Q9ULZ2
PDB IDs
2BZ8
2K6D
2K9G
2N64
2O2O
2YDL
5ABS
1X1F
3MAZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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