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SH3KBP1 and BLNK
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD
(two hybrid, in vivo)
SH3KBP1
BLNK
Description
SH3 domain containing kinase binding protein 1
B cell linker
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Endocytic Vesicle
Cytoplasmic Vesicle Membrane
Neuron Projection
Synapse
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Ribonucleoprotein Granule
Molecular Function
Protein Binding
SH3 Domain Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Enzyme Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Tyrosine Kinase Binding
Biological Process
Endocytosis
Apoptotic Process
Cytoskeleton Organization
Actin Filament Organization
Cell-cell Signaling
Axon Guidance
Regulation Of Cell Shape
Cell Migration
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of B Cell Activation
Membrane Organization
Inflammatory Response
Humoral Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
B Cell Differentiation
Intracellular Signal Transduction
B Cell Receptor Signaling Pathway
Pathways
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Reelin signalling pathway
InlB-mediated entry of Listeria monocytogenes into host cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Platelet count (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
58 interacting genes:
ABI2
ANKS1A
ARAP3
ARHGAP27
ASAP1
ASAP2
BCAR1
BHLHB9
BLNK
BMPR1B
CAPZA1
CBL
CBLB
CCDC57
CCDC88B
CD2
CYSRT1
DENND2A
GGN
GRB2
HCK
HIVEP1
INPP5D
ITSN2
KPRP
KRTAP6-3
LZTS2
MVB12A
NEDD4
NELFA
PAK2
PDCD6
PDCD6IP
PIK3CA
PIK3R1
PNMA5
POLR2K
PSMA3
SEPTIN2
SEPTIN6
SH3BP2
SH3GL2
SH3GL3
SH3GLB1
SH3GLB2
SHKBP1
SOS1
SPRY2
STAP1
SYNJ1
TAF6
TJP2
TP53BP2
UBB
UBC
UBE2I
ZBTB7B
ZNF219
25 interacting genes:
AR
BTK
CBL
CBLB
CD72
CD79A
CMTM3
CRKL
EGFR
ERBB2
ERBB3
GAB1
GRAP2
GRB2
ITK
KIT
LCP2
MAP4K1
NCK1
PLCG1
PLCG2
PTPN6
SH3KBP1
SYK
VAV1
Entrez ID
30011
29760
HPRD ID
02301
05153
Ensembl ID
ENSG00000147010
ENSG00000095585
Uniprot IDs
B7Z6E8
Q5JPT6
Q96B97
Q2MD54
Q2MD59
Q8WV28
PDB IDs
2BZ8
2K6D
2K9G
2N64
2O2O
2YDL
5ABS
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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