TRIP12 and NAE1

Data Source:
BioGRID (enzymatic study)

		TRIP12	NAE1
Description		thyroid hormone receptor interactor 12	NEDD8 activating enzyme E1 subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Embryonic Development Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Signal Transduction Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs			ATP
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31152163 31015462) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		20 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 ERG MTNR1A MTNR1B NAE1 NMI PTF1A SMAD9 SOX6 SRPK2 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		9320	8883
HPRD ID		05144	04545
Ensembl ID		ENSG00000153827	ENSG00000159593
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 Q14669	Q13564
PDB IDs			1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?
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