TRIP12 and PTF1A

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TRIP12	PTF1A
Description		thyroid hormone receptor interactor 12	pancreas associated transcription factor 1a
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Embryonic Development Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Tissue Development Retina Layer Formation Cerebellum Development Pancreas Development Exocrine Pancreas Development Developmental Process Amacrine Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Regulation Of Neural Retina Development
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases			Permanent neonatal diabetes mellitus (PNDM)
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31152163 31015462) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Type 2 diabetes ( 32499647)
Interacting Genes		20 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 ERG MTNR1A MTNR1B NAE1 NMI PTF1A SMAD9 SOX6 SRPK2 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	11 interacting genes: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10
Entrez ID		9320	256297
HPRD ID		05144	09526
Ensembl ID		ENSG00000153827	ENSG00000168267
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 Q14669	Q7RTS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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