PTF1A and RPGRIP1

Data Source:
BioGRID (two hybrid)

		PTF1A	RPGRIP1
Description		pancreas associated transcription factor 1a	RPGR interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Axoneme Photoreceptor Connecting Cilium Ciliary Transition Zone Photoreceptor Distal Connecting Cilium
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Tissue Development Retina Layer Formation Cerebellum Development Pancreas Development Exocrine Pancreas Development Developmental Process Amacrine Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Regulation Of Neural Retina Development	Visual Perception Retinal Rod Cell Development Response To Stimulus Neural Precursor Cell Proliferation Non-motile Cilium Assembly
Pathways		Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)	Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Type 2 diabetes ( 32499647)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		11 interacting genes: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10	26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688
Entrez ID		256297	57096
HPRD ID		09526	05673
Ensembl ID		ENSG00000168267	ENSG00000092200
Uniprot IDs		Q7RTS3	Q96KN7
PDB IDs			4QAM
Enriched GO Terms of Interacting Partners?
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