PTF1A and ZW10

Data Source:
BioGRID (two hybrid)

		PTF1A	ZW10
Description		pancreas associated transcription factor 1a	zw10 kinetochore protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Kinetochore Microtubule Cytosol Membrane Dsl1/NZR Complex RZZ Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Centromeric DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Tissue Development Retina Layer Formation Cerebellum Development Pancreas Development Exocrine Pancreas Development Developmental Process Amacrine Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Regulation Of Neural Retina Development	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Protein Transport Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Protein-containing Complex Assembly Signal Transduction Involved In Mitotic Cell Cycle Checkpoint
Pathways		Regulation of gene expression in early pancreatic precursor cells	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)
GWAS		Type 2 diabetes ( 32499647)	Parental longevity (father's attained age) ( 29227965)
Interacting Genes		11 interacting genes: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10	7 interacting genes: APP DCTN2 PIAS4 PTF1A RINT1 ZWILCH ZWINT
Entrez ID		256297	9183
HPRD ID		09526	04902
Ensembl ID		ENSG00000168267	ENSG00000086827
Uniprot IDs		Q7RTS3	O43264
PDB IDs
Enriched GO Terms of Interacting Partners?
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