RNF25 and UBE2U

Data Source:
BioGRID (two hybrid)

		RNF25	UBE2U
Description		ring finger protein 25	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Nucleus Cytosol	HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding NF-kappaB Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Severe bacterial meningitis ( 31092817)
Interacting Genes		11 interacting genes: KCTD21 MEOX2 RELA TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2L6 UBE2U	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		64320	148581
HPRD ID		09737	14599
Ensembl ID		ENSG00000163481	ENSG00000177414
Uniprot IDs		Q96BH1	A0A140VJY9 Q5VVX9
PDB IDs		2DAY 2DMF 5D1K 5D1L 5D1M	1YRV
Enriched GO Terms of Interacting Partners?
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