APPL1 and ID1

Data Source:
BioGRID (two hybrid)

		APPL1	ID1
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	inhibitor of DNA binding 1, HLH protein
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Nucleus Nucleoplasm Golgi Apparatus Centrosome
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Protein C-terminus Binding Transcription Factor Binding Identical Protein Binding Protein Dimerization Activity Protein N-terminus Binding Proteasome Binding Transcription Regulator Activity Transcription Regulator Inhibitor Activity
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Transcription By Transcription Factor Localization Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Negative Regulation Of Protein Binding Positive Regulation Of Actin Filament Bundle Assembly Circadian Regulation Of Gene Expression Cell-abiotic Substrate Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Dendrite Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Regulation Of Vasculature Development Cellular Response To Peptide Cellular Response To Dopamine Cellular Response To Nerve Growth Factor Stimulus
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Oncogene Induced Senescence NGF-stimulated transcription
Drugs
Diseases
GWAS			Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		64 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829	24 interacting genes: APPL1 ASCL3 CASK COPB1 DNMT3L ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MSGN1 MYF5 MYF6 MYOD1 MYOG PSMD4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4 TRIM55 TRIM63
Entrez ID		26060	3397
HPRD ID		05053	08980
Ensembl ID		ENSG00000157500	ENSG00000125968
Uniprot IDs		Q9UKG1	P41134
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?
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