MTDH and HSPG2

Data Source:
BioGRID (unspecified method)

		MTDH	HSPG2
Description		metadherin	heparan sulfate proteoglycan 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Bicellular Tight Junction Assembly	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Circulatory System Development
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation
Drugs			Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 32888494 27863252 28957414) Sweet taste preference ( 32572145)	Atrial fibrillation ( 30061737) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CENPJ CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 GHDC GLG1 GRID1 HACE1 HERC5 HP1BP3 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PDCD11 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC22A18AS SLC38A4 SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 VIM WDFY2 WNK2 ZNF559 ZXDC	32 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		92140	3339
HPRD ID		17459	00804
Ensembl ID		ENSG00000147649	ENSG00000142798
Uniprot IDs		A0A024R9D2 Q86UE4	P98160
PDB IDs		4QMG	3SH4 3SH5
Enriched GO Terms of Interacting Partners?
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