MTDH and CDC42

Data Source:
BioGRID (pull down)

		MTDH	CDC42
Description		metadherin	cell division cycle 42
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm	Golgi Membrane Storage Vacuole Cytoplasm Endoplasmic Reticulum Membrane Centrosome Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Golgi Transport Complex Secretory Granule Filopodium Midbody Leading Edge Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Dendritic Spine Apical Part Of Cell Phagocytic Vesicle Spindle Midzone Extracellular Exosome Mitotic Spindle Schaffer Collateral - CA1 Synapse
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding GTP-dependent Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Thioesterase Binding GBD Domain Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Bicellular Tight Junction Assembly	Sprouting Angiogenesis Cardiac Conduction System Development Endocytosis Phagocytosis, Engulfment Actin Filament Organization Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Cell Migration Protein Ubiquitination Substantia Nigra Development Cell Projection Assembly Actin Cytoskeleton Organization Macrophage Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokinesis Cdc42 Protein Signal Transduction Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Interleukin-12-mediated Signaling Pathway Dendritic Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway Viral RNA Genome Replication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Binding Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of DNA Replication Positive Regulation Of JNK Cascade Filopodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Pinocytosis Neuron Fate Determination Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Establishment Of Golgi Localization Positive Regulation Of Synapse Structural Plasticity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Submandibular Salivary Gland Formation Dendritic Spine Morphogenesis Cellular Response To Interferon-gamma Organelle Transport Along Microtubule Actin Filament Branching Positive Regulation Of Intracellular Protein Transport Regulation Of Modification Of Postsynaptic Structure Modification Of Synaptic Structure Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways			GPVI-mediated activation cascade EGFR downregulation Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs			Aminophosphonic acid-guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 32888494 27863252 28957414) Sweet taste preference ( 32572145)	Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483) Uterine fibroids ( 31488892 31249589 30194396 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CENPJ CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 GHDC GLG1 GRID1 HACE1 HERC5 HP1BP3 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PDCD11 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC22A18AS SLC38A4 SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 VIM WDFY2 WNK2 ZNF559 ZXDC	382 interacting genes: A2M AARS1 ACADM ACO1 ACO2 ACOT7 ACTR3 ADRM1 AGAP1 AGAP2 AHSG AKR1B1 ALDH18A1 ANAPC13 ANXA11 ANXA2 AP3D1 APEX1 APOH ARAP1 ARAP2 ARG1 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP26 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP40 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 ATP5F1C ATP5IF1 ATP5MF ATP5PD ATP6V1A BAIAP2 BCAP31 BCCIP BCR BIRC2 BLMH BNIP2 BTF3 BZW2 CALML5 CAPNS1 CAPZB CARHSP1 CASP14 CASP3 CASP7 CBLL1 CBX3 CCN1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC5L CDH1 CDKN2A CFHR4 CGN CMPK1 CNBP CNOT1 COL1A1 COMT COPA COPE COPG1 CPN1 CRIP2 CSE1L CSN2 CSPG4 CTNNA1 DEF6 DEK DHFR DIAPH1 DIAPH2 DIAPH3 DNMBP DOCK7 DOCK8 DOCK9 DPYSL2 DSG1 DSP ECHS1 EDC4 EDF1 EEF1E1 EEF1G EHD2 EHD4 EIF2AK2 EIF3D EIF3F EIF5 EIF5B EPHA2 EPRS1 ERCC3 ERG28 ERICH6 ERRFI1 ETFA FAM13B FGD1 FGD2 FGD3 FGD4 FKBP10 FKBP1A FKBP3 FLNA FLNC FMN2 FMNL2 FNBP1 FNBP1L FTH1 G6PD GALNT2 GART GDI1 GIT1 GIT2 GLS GMIP GNB1 GRB2 GRWD1 GSR GSTM5 H1-10 H1-5 H2BC13 HADH HADHB HDAC7 HDLBP HERC2 HLA-G HMGN1 HNRNPAB HNRNPUL2 HSD17B10 HYOU1 IARS1 IGF2BP1 IPO5 IQGAP1 IQGAP2 ITSN1 JPT2 KARS1 KAT5 KHDRBS1 KIAA2026 KPNA2 KTN1 KYNU LARS1 LCK LGALS1 LGALS7 LONP1 LRIF1 LRP2 LYZ MAP2K3 MAP3K10 MAP3K11 MAP3K19 MAP3K4 MAP4 MAPRE1 MARCKSL1 MARK4 MASTL MATR3 MCF2L MCM3AP MCM6 MCM7 MDH1 MDK METAP2 MRM1 MRPL49 MSH2 MT-CO1 MTDH MUC12 MYO1C MYO6 MYO9A NAA15 NASP NCAPD2 NCF2 NEK6 NIBAN2 NOP2 NPLOC4 NQO1 NUDT21 NUP155 OCRL OLA1 OPHN1 P3H1 PABPC4 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PALLD PARD3 PARD6A PARD6B PARD6G PAXX PCM1 PCNP PDCD5 PDE6C PDE6D PGD PGGT1B PHAX PHB2 PHPT1 PICALM PIK3R1 PLD1 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PMS1 PPP2R1A PRDX3 PREX2 PRKCA PRKCG PRKCI PRKCZ PSAT1 PSIP1 PSMB1 PSMC5 PSMC6 PSMD11 PSMD12 PSMD3 PSME3 PXDN RAC2 RAP1GDS1 RARS1 RASGRF2 RBM39 RBM8A RHOJ RIOK3 RO60 RPL22 RPL23 RPS15 RPS21 RPS6KB1 RRM1 S100A9 SDHA SEPTIN2 SERPINB1 SERPINB2 SERPINB3 SF1 SF3A2 SH3BGRL3 SH3D19 SLC16A3 SMC2 SNRNP70 SPATA13 SRGAP1 SRM SRP72 SRSF1 SSB SSX2IP ST13 STARD8 STAT1 STAU1 STMN2 SYNE1 TBC1D3F TBCA TCEAL3 TIAM1 TMED10 TMED9 TMOD3 TMX1 TNFRSF10B TNK2 TOR1AIP1 TP53 TPD52L2 TPM1 TRAF2 TRAF7 TRIM28 TRIM45 TRIM60 TRIO TRIP10 TRRAP TSFM TTC12 TUBB3 TXNL1 TYMS U2AF2 UBC UBE2L3 UBR1 UGDH UNC119 USP6 VARS1 VASP VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 XIAP XPO1 YARS1 YWHAH ZNF175 ZNF234 ZNF415 ZNF420 ZNF622
Entrez ID		92140	998
HPRD ID		17459	00309
Ensembl ID		ENSG00000147649	ENSG00000070831
Uniprot IDs		A0A024R9D2 Q86UE4	A0A024RAA5 A0A024RAE6 P60953
PDB IDs		4QMG	1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR 4JS0 4YC7 4YDH 5CJP 5FI1 5HZK 5UPK 5UPL 6AJ4 6AJL 6SIU 6SUP 6TKY 6TKZ
Enriched GO Terms of Interacting Partners?
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