HSPG2 and NID1

Data Source:
HPRD (in vitro)

		HSPG2	NID1
Description		heparan sulfate proteoglycan 2	nidogen 1
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex	Extracellular Region Basement Membrane Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Circulatory System Development	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation	Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs		Palifermin	Urokinase
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Atrial fibrillation ( 30061737) Height ( 28552196) PR interval ( 32439900)	Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)
Interacting Genes		32 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		3339	4811
HPRD ID		00804	00574
Ensembl ID		ENSG00000142798	ENSG00000116962
Uniprot IDs		P98160	P14543
PDB IDs		3SH4 3SH5	1NDX
Enriched GO Terms of Interacting Partners?
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