HSPG2 and VWA1

Data Source:
HPRD (in vitro)

		HSPG2	VWA1
Description		heparan sulfate proteoglycan 2	von Willebrand factor A domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex	Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding	Extracellular Matrix Structural Constituent Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Circulatory System Development	Extracellular Matrix Organization Post-translational Protein Modification Cellular Protein Metabolic Process Behavioral Response To Pain
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Palifermin
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Atrial fibrillation ( 30061737) Height ( 28552196) PR interval ( 32439900)	Body mass index ( 26426971)
Interacting Genes		32 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	1 interacting genes: HSPG2
Entrez ID		3339	64856
HPRD ID		00804	18292
Ensembl ID		ENSG00000142798	ENSG00000179403
Uniprot IDs		P98160	Q6PCB0
PDB IDs		3SH4 3SH5
Enriched GO Terms of Interacting Partners?
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