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HSPG2 and LAMA1
Data Source:
HPRD
(in vitro)
HSPG2
LAMA1
Description
heparan sulfate proteoglycan 2
laminin subunit alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Golgi Lumen
Plasma Membrane
Focal Adhesion
Lysosomal Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Plasma Membrane Protein Complex
Extracellular Region
Basement Membrane
Laminin-1 Complex
Laminin-3 Complex
Extracellular Space
Cell-cell Junction
Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Amyloid-beta Binding
Calcium Ion Binding
Protein Binding
Protein C-terminus Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Low-density Lipoprotein Particle Receptor Binding
Signaling Receptor Binding
Extracellular Matrix Structural Constituent
Protein Binding
Protein C-terminus Binding
Glycosphingolipid Binding
Biological Process
Retinoid Metabolic Process
Angiogenesis
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Lipid Metabolic Process
Receptor-mediated Endocytosis
Inflammatory Response
Brain Development
Animal Organ Morphogenesis
Tissue Development
Negative Regulation Of Angiogenesis
Cell Differentiation
Extracellular Matrix Organization
Cellular Protein Metabolic Process
Circulatory System Development
Morphogenesis Of An Epithelial Sheet
Protein Phosphorylation
Cell Adhesion
Cell Surface Receptor Signaling Pathway
Axon Guidance
Animal Organ Morphogenesis
Tissue Development
Regulation Of Cell Adhesion
Extracellular Matrix Organization
Regulation Of Cell Migration
Camera-type Eye Development
Establishment Of Epithelial Cell Apical/basal Polarity
Regulation Of Embryonic Development
Blood Vessel Morphogenesis
Epithelial Tube Branching Involved In Lung Morphogenesis
Branching Involved In Salivary Gland Morphogenesis
Retinal Blood Vessel Morphogenesis
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport
Amyloid fiber formation
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
L1CAM interactions
MET activates PTK2 signaling
Drugs
Palifermin
Lanoteplase
Diseases
Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS
Atrial fibrillation (
30061737
)
Height (
28552196
)
PR interval (
32439900
)
Adverse response to drug (
30420678
)
Response to citalopram treatment (
22760553
)
Type 2 diabetes (
30054458
22693455
30297969
32499647
)
Interacting Genes
32 interacting genes:
APP
ATF7IP
ATN1
BMP1
CACNA1A
CCN2
COL13A1
ECM1
FBLN1
FBLN2
FBN1
FGF2
FGF7
FGFBP1
FN1
GFI1B
GRN
ITGA2
ITGB1
LAMA1
MTDH
NID1
NID2
PDGFA
PDGFB
PRELP
PRPF40A
SPARC
TCAP
TTR
UBC
VWA1
20 interacting genes:
ACHE
APCS
APP
C3
COL7A1
DAG1
FBLN2
HSPG2
ITGA1
ITGA2
ITGB1
MEP1A
NID1
NT5E
PLAT
PLG
SAA1
SAA2
TMPRSS6
UBC
Entrez ID
3339
284217
HPRD ID
00804
01033
Ensembl ID
ENSG00000142798
ENSG00000101680
Uniprot IDs
P98160
P25391
PDB IDs
3SH4
3SH5
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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