ACVR2A and MAGI2

Data Source:
HPRD (two hybrid, in vitro)

		ACVR2A	MAGI2
Description		activin A receptor type 2A	membrane associated guanylate kinase, WW and PDZ domain containing 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Nucleus Cytoplasm Late Endosome Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Dendrite Protein-containing Complex Slit Diaphragm Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding BMP Receptor Activity	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP	Nephrin family interactions
Drugs		Sotatercept
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) High myopia ( 31816047) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Refractive error ( 32231278) Response to statin therapy ( 20339536) Retinal detachment or retinal break ( 31816047) Urate levels ( 31985003 23263486) White blood cell count (basophil) ( 27863252)	Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to anti-depressant treatment in major depressive disorder ( 22041458) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 30285260) Serum folate levels ( 29953918) Visceral fat ( 30942860)
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TDGF1 TGFBR3	24 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAML1 GRID2 MORN4 PDZD11 PLEKHF2 PLXNB3 PTEN RAPGEF2 RPS6KA1 SMAD3 SNRPB TGFA
Entrez ID		92	9863
HPRD ID		00025	16212
Ensembl ID		ENSG00000121989	ENSG00000187391
Uniprot IDs		P27037	B7Z4H4 Q86UL8
PDB IDs		3Q4T 3SOC 4ASX 5NH3	1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?
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