Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
ACVR2A and NODAL
Data Source:
BioGRID
(pull down)
ACVR2A
NODAL
Description
activin A receptor type 2A
nodal growth differentiation factor
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Activin Receptor Complex
Extracellular Space
Molecular Function
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Activin-activated Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Protein Self-association
Metal Ion Binding
Activin Binding
BMP Receptor Activity
Cytokine Activity
Protein Binding
Growth Factor Activity
Morphogen Activity
Type I Activin Receptor Binding
Biological Process
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Mesoderm Development
Anterior/posterior Pattern Specification
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Sperm Ejaculation
Penile Erection
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Development
Regulation Of Nitric-oxide Synthase Activity
Sertoli Cell Proliferation
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Trophectodermal Cellular Morphogenesis
Neural Fold Formation
Liver Development
Placenta Development
Embryonic Placenta Development
Maternal Placenta Development
Vasculature Development
Heart Looping
Inhibition Of Neuroepithelial Cell Differentiation
Brain Development
Embryonic Pattern Specification
Polarity Specification Of Proximal/distal Axis
Regulation Of Gastrulation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Cell Development
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Stem Cell Population Maintenance
Positive Regulation Of Cell-cell Adhesion
BMP Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Floor Plate Morphogenesis
Endodermal Cell Differentiation
Cell Migration Involved In Gastrulation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Axial Mesodermal Cell Fate Specification
Mesendoderm Development
Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Formation Of Anatomical Boundary
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of DNA-binding Transcription Factor Activity
Embryonic Process Involved In Female Pregnancy
Maternal Process Involved In Parturition
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Left Lung Morphogenesis
Negative Regulation Of Androgen Receptor Signaling Pathway
Epiblast Cell-extraembryonic Ectoderm Cell Signaling Involved In Anterior/posterior Axis Specification
Positive Regulation Of ERK1 And ERK2 Cascade
Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Primitive Streak Formation
Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Negative Regulation Of Trophoblast Cell Migration
Negative Regulation Of Chorionic Trophoblast Cell Proliferation
Regulation Of Stem Cell Population Maintenance
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
Signaling by NODAL
Regulation of signaling by NODAL
Drugs
Sotatercept
Diseases
Heterotaxy; Situs ambiguus
GWAS
Adult body size (
32376654
)
Adventurousness (
30643258
)
Arterial stiffness index (
31235810
)
Asthma (adult onset) (
31036433
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Cerebrospinal T-tau levels (
28247064
)
Diastolic blood pressure (
30224653
)
Eosinophil counts (
32888494
)
Estimated glomerular filtration rate (
31015462
)
Feeling hurt (
29500382
)
Feeling miserable (
29500382
)
Feeling nervous (
29500382
)
Feeling tense (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
High myopia (
31816047
)
Loneliness (MTAG) (
29970889
)
Neutrophil percentage of granulocytes (
27863252
)
Photic sneeze reflex (
30899065
)
Refractive error (
32231278
)
Response to statin therapy (
20339536
)
Retinal detachment or retinal break (
31816047
)
Urate levels (
31985003
23263486
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
23 interacting genes:
ACVRL1
BMP10
BMP2
BMP4
BMP6
BMP7
DAXX
DYNLT4
ENG
ERBIN
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
NODAL
PRSS50
SYNJ2BP
TDGF1
TGFBR3
6 interacting genes:
ACVR1B
ACVR2A
ACVR2B
KRT31
KRTAP6-3
TDGF1
Entrez ID
92
4838
HPRD ID
00025
08370
Ensembl ID
ENSG00000121989
ENSG00000156574
Uniprot IDs
P27037
Q96S42
PDB IDs
3Q4T
3SOC
4ASX
5NH3
4N1D
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?