Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
ACVR2A and ENG
Data Source:
HPRD
(in vivo)
ACVR2A
ENG
Description
activin A receptor type 2A
endoglin
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Activin Receptor Complex
Extracellular Space
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Nuclear Body
Receptor Complex
Endothelial Microparticle
Molecular Function
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Activin-activated Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Protein Self-association
Metal Ion Binding
Activin Binding
BMP Receptor Activity
Transmembrane Signaling Receptor Activity
Transforming Growth Factor Beta-activated Receptor Activity
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
Galactose Binding
Glycosaminoglycan Binding
Coreceptor Activity
Type I Transforming Growth Factor Beta Receptor Binding
BMP Binding
Identical Protein Binding
Protein Homodimerization Activity
Activin Binding
Transforming Growth Factor Beta Binding
Biological Process
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Mesoderm Development
Anterior/posterior Pattern Specification
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Sperm Ejaculation
Penile Erection
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Development
Regulation Of Nitric-oxide Synthase Activity
Sertoli Cell Proliferation
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Epithelial To Mesenchymal Transition
Positive Regulation Of Protein Phosphorylation
Heart Looping
Sprouting Angiogenesis
Outflow Tract Septum Morphogenesis
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Endocardial Cushion Morphogenesis
Cardiac Ventricle Morphogenesis
Cardiac Atrium Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Cell Migration Involved In Endocardial Cushion Formation
Regulation Of Transcription, DNA-templated
Cell Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Gene Expression
Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Cell Migration
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Central Nervous System Vasculogenesis
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Negative Regulation Of Protein Autophosphorylation
Response To Corticosteroid
Positive Regulation Of Collagen Biosynthetic Process
Dorsal Aorta Morphogenesis
Response To Drug
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Smooth Muscle Tissue Development
Artery Morphogenesis
Venous Blood Vessel Morphogenesis
Positive Regulation Of Protein Kinase B Signaling
Atrial Cardiac Muscle Tissue Morphogenesis
Bone Development
Extracellular Matrix Constituent Secretion
Cellular Response To Mechanical Stimulus
Endocardial Cushion To Mesenchymal Transition
Vascular Associated Smooth Muscle Cell Development
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Atrioventricular Canal Morphogenesis
Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
Drugs
Sotatercept
Carotuximab
Diseases
Hereditary hemorrhagic telangiectasia (HHT)
GWAS
Adult body size (
32376654
)
Adventurousness (
30643258
)
Arterial stiffness index (
31235810
)
Asthma (adult onset) (
31036433
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Cerebrospinal T-tau levels (
28247064
)
Diastolic blood pressure (
30224653
)
Eosinophil counts (
32888494
)
Estimated glomerular filtration rate (
31015462
)
Feeling hurt (
29500382
)
Feeling miserable (
29500382
)
Feeling nervous (
29500382
)
Feeling tense (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
High myopia (
31816047
)
Loneliness (MTAG) (
29970889
)
Neutrophil percentage of granulocytes (
27863252
)
Photic sneeze reflex (
30899065
)
Refractive error (
32231278
)
Response to statin therapy (
20339536
)
Retinal detachment or retinal break (
31816047
)
Urate levels (
31985003
23263486
)
White blood cell count (basophil) (
27863252
)
Blood protein levels (
30072576
)
Body mass index (
26426971
)
Metabolic syndrome (
20694148
)
Interacting Genes
23 interacting genes:
ACVRL1
BMP10
BMP2
BMP4
BMP6
BMP7
DAXX
DYNLT4
ENG
ERBIN
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
NODAL
PRSS50
SYNJ2BP
TDGF1
TGFBR3
13 interacting genes:
ACVR1
ACVR2A
BMP2
BMP7
DYNLT4
GDF2
INHBA
TGFB1
TGFB2
TGFB3
TGFBR1
TGFBR2
TGFBR3
Entrez ID
92
2022
HPRD ID
00025
00565
Ensembl ID
ENSG00000121989
ENSG00000106991
Uniprot IDs
P27037
A0A024R878
B7Z6Y5
F5GX88
P17813
Q5T9B9
Q96CG0
PDB IDs
3Q4T
3SOC
4ASX
5NH3
5HZV
5HZW
5I04
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?