SUGT1 and MIS12

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SUGT1	MIS12
Description		SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	MIS12 kinetochore complex component
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Cytosol Protein-containing Complex	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Protein Stability Positive Regulation By Host Of Symbiont Catalytic Activity Protein Stabilization	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PHLPP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1	10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		10910	79003
HPRD ID		09160	12379
Ensembl ID		ENSG00000165416	ENSG00000167842
Uniprot IDs		A8K7W3 B4DYC6 Q9Y2Z0	A8K1M4 Q9H081
PDB IDs		1RL1	5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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