SUGT1 and BUB3

Data Source:
BioGRID (two hybrid)

		SUGT1	BUB3
Description		SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	BUB3 mitotic checkpoint protein
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Cytosol Protein-containing Complex	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Protein Stability Positive Regulation By Host Of Symbiont Catalytic Activity Protein Stabilization	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Body mass index ( 28892062) Left-handedness ( 32989287) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		17 interacting genes: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PHLPP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1	17 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 RPL37A SUGT1 THRA TOP1 UBA1 WBP4
Entrez ID		10910	9184
HPRD ID		09160	04761
Ensembl ID		ENSG00000165416	ENSG00000154473
Uniprot IDs		A8K7W3 B4DYC6 Q9Y2Z0	A0A140VJF3 O43684
PDB IDs		1RL1
Enriched GO Terms of Interacting Partners?
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