ATG12 and DOCK9

Data Source:
BioGRID (two hybrid)

		ATG12	DOCK9
Description		autophagy related 12	dedicator of cytokinesis 9
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GO Annotations	Cellular Component	Autophagosome Cytosol Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex	Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion C-terminal Protein Lipidation Viral Process Macroautophagy Autophagy Of Nucleus	Small GTPase Mediated Signal Transduction Blood Coagulation Biological_process Positive Regulation Of GTPase Activity
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Asthma (childhood onset) ( 31036433) Blood urea nitrogen levels ( 31152163 29403010) Corneal astigmatism ( 30306274) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Lung function (FEV1/FVC) ( 30804560) Nonsyndromic cleft palate ( 31609978) Platelet distribution width ( 32888494) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 PLSCR1 PTK2 SERTAD1 SERTAD2	11 interacting genes: ATG12 CDC42 CLK1 FHL1 LNX1 MYOT NEDD9 NUCKS1 PPP2R5E SNAPIN TAF1
Entrez ID		9140	23348
HPRD ID		08496	09542
Ensembl ID		ENSG00000145782	ENSG00000088387
Uniprot IDs		O94817	A0A0A0MT38 A6H8Z6 B3KXE2 B7Z2G6 B9EG73 Q9BZ29
PDB IDs		4GDK 4GDL 4NAW	1WG7 2WM9 2WMN 2WMO
Enriched GO Terms of Interacting Partners?
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