DOCK9 and PPP2R5E

Data Source:
BioGRID (two hybrid)

		DOCK9	PPP2R5E
Description		dedicator of cytokinesis 9	protein phosphatase 2 regulatory subunit B'epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Endomembrane System Membrane	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Small GTPase Mediated Signal Transduction Blood Coagulation Biological_process Positive Regulation Of GTPase Activity	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Factors involved in megakaryocyte development and platelet production	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Blood urea nitrogen levels ( 31152163 29403010) Corneal astigmatism ( 30306274) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Lung function (FEV1/FVC) ( 30804560) Nonsyndromic cleft palate ( 31609978) Platelet distribution width ( 32888494) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) White blood cell count ( 32888494)	Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)
Interacting Genes		11 interacting genes: ATG12 CDC42 CLK1 FHL1 LNX1 MYOT NEDD9 NUCKS1 PPP2R5E SNAPIN TAF1	20 interacting genes: APP BHLHB9 BHLHE41 CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DOCK9 ENO1 FBXW11 PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9
Entrez ID		23348	5529
HPRD ID		09542	09040
Ensembl ID		ENSG00000088387	ENSG00000154001
Uniprot IDs		A0A0A0MT38 A6H8Z6 B3KXE2 B7Z2G6 B9EG73 Q9BZ29	Q16537
PDB IDs		1WG7 2WM9 2WMN 2WMO
Enriched GO Terms of Interacting Partners?
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