DOCK9 and NUCKS1

Data Source:
BioGRID (two hybrid)

		DOCK9	NUCKS1
Description		dedicator of cytokinesis 9	nuclear casein kinase and cyclin dependent kinase substrate 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Endomembrane System Membrane	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding	Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Transcription Factor Binding
	Biological Process	Small GTPase Mediated Signal Transduction Blood Coagulation Biological_process Positive Regulation Of GTPase Activity	Double-strand Break Repair Via Homologous Recombination Cellular Glucose Homeostasis Regulation Of DNA Replication Chromatin Organization Regulation Of Transcription By RNA Polymerase II Release From Viral Latency Replication Fork Processing Gene Conversion Interstrand Cross-link Repair Positive Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA Strand Elongation Cellular Response To X-ray Modulation By Host Of RNA Binding By Virus Modulation By Host Of Viral RNA-binding Transcription Factor Activity
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Blood urea nitrogen levels ( 31152163 29403010) Corneal astigmatism ( 30306274) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Lung function (FEV1/FVC) ( 30804560) Nonsyndromic cleft palate ( 31609978) Platelet distribution width ( 32888494) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Free thyroxine concentration ( 30367059) HDL cholesterol levels ( 32203549) Menarche (age at onset) ( 25231870) Parkinson's disease ( 19915575 19915576 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate-specific antigen levels ( 25434496 23269536) Pubertal anthropometrics ( 23449627) QT interval ( 24952745) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Weight ( 28552196)
Interacting Genes		11 interacting genes: ATG12 CDC42 CLK1 FHL1 LNX1 MYOT NEDD9 NUCKS1 PPP2R5E SNAPIN TAF1	4 interacting genes: AK5 DOCK9 GLP1R MDM2
Entrez ID		23348	64710
HPRD ID		09542	11406
Ensembl ID		ENSG00000088387	ENSG00000069275
Uniprot IDs		A0A0A0MT38 A6H8Z6 B3KXE2 B7Z2G6 B9EG73 Q9BZ29	Q9H1E3
PDB IDs		1WG7 2WM9 2WMN 2WMO
Enriched GO Terms of Interacting Partners?
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