ARHGEF1 and CNKSR1

Data Source:
HPRD (in vivo)

		ARHGEF1	CNKSR1
Description		Rho guanine nucleotide exchange factor 1	connector enhancer of kinase suppressor of Ras 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		11 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		9138	10256
HPRD ID		03511	11937
Ensembl ID		ENSG00000076928	ENSG00000142675
Uniprot IDs		A0A024R0R1 Q92888	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	1WWV
Enriched GO Terms of Interacting Partners?
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