RABEP1 and TSC2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RABEP1	TSC2
Description		rabaptin, RAB GTPase binding effector protein 1	TSC complex subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Endocytic Vesicle Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Recycling Endosome	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of GTPase Activity Membrane Fusion Protein Localization To Ciliary Membrane	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy
Pathways		TBC/RABGAPs	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Body mass index ( 28892062 25673413) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		58 interacting genes: ABI2 AIMP2 AP1G1 AP1G2 ATXN7 BARD1 CASP3 CCDC120 CCND1 CDC73 CDK18 CDKL3 CEP57 CFAP53 ELOA ESCO2 FAM50B FAM90A1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 LENG1 MAT2B MCRS1 ODAD3 PELI2 PKP2 PRPF3 RAB1A RAB33B RAB4A RAB4B RAB5A RABGEF1 RGS17 RNF39 SMURF1 SNAPIN SNW1 SRPK2 STAR TNS4 TRAPPC2L TRIM26 TSC2 TSHZ2 UBC UBTFL1 USP2 UTP14C WASHC3 YWHAG ZNF438 ZNF512B ZNF774	44 interacting genes: AKT1 AKT2 AKT3 CALM1 CBY2 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		9135	7249
HPRD ID		04684	01850
Ensembl ID		ENSG00000029725	ENSG00000103197
Uniprot IDs		B4DMM4 Q15276	B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2
PDB IDs		1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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