RABEP1 and MAT2B

Data Source:
BioGRID (two hybrid)

		RABEP1	MAT2B
Description		rabaptin, RAB GTPase binding effector protein 1	methionine adenosyltransferase 2B
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GO Annotations	Cellular Component	Endosome Early Endosome Endocytic Vesicle Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Recycling Endosome	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of GTPase Activity Membrane Fusion Protein Localization To Ciliary Membrane	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity
Pathways		TBC/RABGAPs	Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 28892062 25673413) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)	Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		58 interacting genes: ABI2 AIMP2 AP1G1 AP1G2 ATXN7 BARD1 CASP3 CCDC120 CCND1 CDC73 CDK18 CDKL3 CEP57 CFAP53 ELOA ESCO2 FAM50B FAM90A1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 LENG1 MAT2B MCRS1 ODAD3 PELI2 PKP2 PRPF3 RAB1A RAB33B RAB4A RAB4B RAB5A RABGEF1 RGS17 RNF39 SMURF1 SNAPIN SNW1 SRPK2 STAR TNS4 TRAPPC2L TRIM26 TSC2 TSHZ2 UBC UBTFL1 USP2 UTP14C WASHC3 YWHAG ZNF438 ZNF512B ZNF774	10 interacting genes: APP FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27
Entrez ID		9135	27430
HPRD ID		04684	05701
Ensembl ID		ENSG00000029725	ENSG00000038274
Uniprot IDs		B4DMM4 Q15276	A0A140VJP2 Q9NZL9
PDB IDs		1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U	2YDX 2YDY 4KTT 4KTV 4NDN
Enriched GO Terms of Interacting Partners?
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