FBXL18 and FBXL7

Data Source:
BioGRID (pull down)

		FBXL18	FBXL7
Description		F-box and leucine rich repeat protein 18	F-box and leucine rich repeat protein 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function		Protein Binding
	Biological Process	Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cell Division
Pathways			FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) High light scatter reticulocyte count ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Relative hand skill in reading disability ( 24068947)	Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)
Interacting Genes		22 interacting genes: CALCOCO2 FBXL7 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2	5 interacting genes: APP BIRC5 FBXL18 FCHO1 TBC1D5
Entrez ID		80028	23194
HPRD ID		07753	05740
Ensembl ID		ENSG00000155034	ENSG00000183580
Uniprot IDs		A0A024R857 B4DH63 Q96D16	Q9UJT9
PDB IDs
Enriched GO Terms of Interacting Partners?
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