HSPB3 and MED31

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPB3	MED31
Description		heat shock protein family B (small) member 3	mediator complex subunit 31
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function		Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Unfolded Protein	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Systolic blood pressure (dietary potassium intake interaction) ( 29212900)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		19 interacting genes: ANP32A BBOX1 HSPB2 HSPB8 LRIF1 LSM14B MED31 MED8 MRPL38 NSMF OLFML3 PRPF4B RAMP3 RBM48 RTL8A SETDB1 TCAP UNC119 ZZEF1	59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		8988	51003
HPRD ID		06861	14382
Ensembl ID		ENSG00000169271	ENSG00000108590
Uniprot IDs		Q12988 Q6ICS9	Q9Y3C7
PDB IDs		6F2R
Enriched GO Terms of Interacting Partners?
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