MED31 and DLEU1

Data Source:
HPRD (two hybrid)

		MED31	DLEU1
Description		mediator complex subunit 31	deleted in lymphocytic leukemia 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Adiponectin levels ( 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Aluminium levels ( 26025379) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163) Circulating odd-numbered chain saturated fatty acid levels (C19:0) ( 29738550) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) FEV1 ( 30804560) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340 31217584) Hematocrit ( 29403010 32888494) Hemoglobin ( 29403010 32888494) Hip circumference adjusted for BMI ( 28552196) Lipoprotein (a) levels ( 30108283) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21833088 27386562) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Plasma anti-thyroid peroxidase levels ( 29678681) Platelet distribution width ( 32888494) Primary biliary cholangitis ( 26394269) Prostate-specific antigen levels ( 28139693) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tumor necrosis factor alpha levels ( 31217265) Type 2 diabetes ( 30054458 30297969 32499647) Urinary albumin-to-creatinine ratio ( 31630189) Urinary magnesium excretion ( 31993563) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	20 interacting genes: ABCD4 ABCF3 ARL8B CCDC90B CEP126 COPS6 EEF1A1 EEF1G GDF9 GOPC KAT5 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A
Entrez ID		51003	10301
HPRD ID		14382	16150
Ensembl ID		ENSG00000108590	ENSG00000176124
Uniprot IDs		Q9Y3C7
PDB IDs
Enriched GO Terms of Interacting Partners?
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