USP13 and UBL4A

Data Source:
BioGRID (enzymatic study)

		USP13	UBL4A
Description		ubiquitin specific peptidase 13	ubiquitin like 4A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane BAT3 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Chaperone Binding Proteasome Binding BAT3 Complex Binding Lys48-specific Deubiquitinase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Chaperone Binding
	Biological Process	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Protein Phosphopantetheinylation Melanocyte Differentiation Protein K29-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of ERAD Pathway Maintenance Of Unfolded Protein Involved In ERAD Pathway	Cellular Protein Modification Process Protein Phosphopantetheinylation Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Ub-specific processing proteases Regulation of PTEN stability and activity	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS			Neutrophil count ( 32888494)
Interacting Genes		18 interacting genes: AMFR BAG6 DAZAP2 DVL1 FNBP1L FUNDC2 LAPTM5 MCL1 MDC1 MRPL20 MYO15A SIAH2 SPRR2C TRIM55 TRIM63 UBC UBL4A UIMC1	14 interacting genes: AMFR APP CDCA7L ERP27 MEOX2 PER2 RNF126 S100P SEC61B SGTA SGTB TRAF4 TRIM54 USP13
Entrez ID		8975	8266
HPRD ID		04666	02417
Ensembl ID		ENSG00000058056	ENSG00000102178
Uniprot IDs		A0A0A6YZ17 Q92995	P11441
PDB IDs		2L80 2LBC	2DZI 4WWR 4X86
Enriched GO Terms of Interacting Partners?
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