BTRC and PDCD4

Data Source:
HPRD (in vivo)

		BTRC	PDCD4
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	programmed cell death 4
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GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	RNA Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Interleukin-1-mediated Signaling Pathway Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Apoptotic Process Cell Aging BMP Signaling Pathway Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking status (ever vs never smokers) ( 30643258)	Fish- and plant-related diet ( 32066663)
Interacting Genes		82 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAZ TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A	16 interacting genes: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 IBTK LRRK1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2
Entrez ID		8945	27250
HPRD ID		04596	10549
Ensembl ID		ENSG00000166167	ENSG00000150593
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297	B4DKX4 Q53EL6
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?
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