BTRC and MCL1

Data Source:
BioGRID (enzymatic study)

		BTRC	MCL1
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	MCL1 apoptosis regulator, BCL2 family member
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GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Protein Binding Protein Transmembrane Transporter Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Interleukin-1-mediated Signaling Pathway Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Cell Fate Determination Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Cellular Homeostasis Response To Cytokine Negative Regulation Of Apoptotic Process Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-4 and Interleukin-13 signaling
Drugs			Isosorbide
Diseases
GWAS		Diastolic blood pressure ( 30224653) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking status (ever vs never smokers) ( 30643258)	Blood protein levels ( 30072576) Coffee consumption ( 31959922) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Mean corpuscular hemoglobin ( 32888494) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		82 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAZ TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A	37 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 CHRM4 DAD1 EP300 FBXW11 GSK3A GSK3B HIF1A HRK HUWE1 KCNF1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 STX8 TNKS TPT1 TRAF6 UBXN6 UHRF2 USP13 USP9X VDAC1
Entrez ID		8945	4170
HPRD ID		04596	08870
Ensembl ID		ENSG00000166167	ENSG00000143384
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297	A0A087WT64 C8YZ26 Q07820
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O4U 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB 6STJ 6U63 6U64 6U65 6U67 6U6F 6UA3 6UAB 6UD2 6UDI 6UDT 6UDU 6UDV 6UDX 6UDY
Enriched GO Terms of Interacting Partners?
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