BTRC and LPCAT1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		BTRC	LPCAT1
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	lysophosphatidylcholine acyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Membrane Integral Component Of Membrane Azurophil Granule Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Calcium Ion Binding 1-alkenylglycerophosphocholine O-acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity 1-alkylglycerophosphocholine O-acyltransferase Activity 1-alkylglycerophosphocholine O-acetyltransferase Activity Plasmalogen Synthase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Interleukin-1-mediated Signaling Pathway Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Phosphatidic Acid Biosynthetic Process Phosphatidylcholine Biosynthetic Process Phospholipid Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Surfactant Homeostasis Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Retina Development In Camera-type Eye Negative Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Acyl chain remodelling of PC Acyl chain remodelling of PG Synthesis of PA Synthesis of PC Neutrophil degranulation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking status (ever vs never smokers) ( 30643258)	Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Multiple sclerosis ( 31604244) Pancreatic cancer ( 25086665)
Interacting Genes		82 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAZ TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A	2 interacting genes: BTRC GSK3B
Entrez ID		8945	79888
HPRD ID		04596	08572
Ensembl ID		ENSG00000166167	ENSG00000153395
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297	D3DTC2 Q8NF37
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?
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