SKAP2 and DNAJB6

Data Source:
BioGRID (two hybrid)

		SKAP2	DNAJB6
Description		src kinase associated phosphoprotein 2	DnaJ heat shock protein family (Hsp40) member B6
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	ATPase Activator Activity Protein Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation Protein-containing Complex Assembly	Protein Folding Positive Regulation Of ATPase Activity Regulation Of Protein Localization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Organization Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat
Pathways		Signal regulatory protein family interactions	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Monocyte count ( 32888494) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)	Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)
Interacting Genes		20 interacting genes: APP BLK DNAJB6 FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1	23 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MLF2 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8
Entrez ID		8935	10049
HPRD ID		05558	07107
Ensembl ID		ENSG00000005020	ENSG00000105993
Uniprot IDs		B7Z5R3 O75563	A0A0J9YX62 O75190
PDB IDs		3OMH	6U3R 6U3S
Enriched GO Terms of Interacting Partners?
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